SASTRA-CNR Rao Award to G. Mugesh

SASTRA-CNR Rao Award to G. Mugesh

G. Mugesh has been selected to receive the SASTRA-CNR Rao Award in Chemistry & Materials Science for the year 2021. The Award carries a cash prize and a citation. The
Awards will be presented on the National Science Day, February 28, 2021

G. Mugesh ranked among the top 2% scientists in the world

G. Mugesh ranked among the top 2% scientists in the world

IISc has emerged as the Indian institute with the largest number of top scientists in diverse fields in a global database of scientists from around the world, according to a study published in PLOS Biology, a peer-reviewed journal. G. Mugesh is listed as one of the 94 scientists from IISc. The database provides standardized information on citations, h-index, citations to papers in different authorship positions etc.

G. Mugesh is featured in the List of Asian Scientist 100 Fourth Edition

G. Mugesh is featured in the List of Asian Scientist 100 Fourth Edition

Every year since 2016, Asian Scientist Magazine compiles a list of Asia's most outstanding researchers. Now into its fourth edition, the Asian Scientist 100 list celebrates the success of the region’s best and brightest, highlighting their achievements across a range of scientific disciplines.

G. Mugesh awarded J. C. Bose National Fellowship for a Second Term

G. Mugesh awarded J. C. Bose National Fellowship for a Second Term

G. Mugesh has been awarded the prestigious J. C. Bose National Fellowship for a second term (2021-25) by the Science and Engineering Research Board, DST, Government of India, based on the performance during the last five years.

Nanomaterial that can defeat pathogens - Deccan Herald

Nanomaterial that can defeat pathogens - Deccan Herald

In a significant breakthrough in the battle against antibiotic resistance, a research team from the Indian Institute of Science (IISc) has synthesised a nanomaterial that mimics an enzyme and can disintegrate the cell membranes of a range of disease-causing bacteria.

Nanomaterials as antimicrobial agents - The Times of India

Nanomaterials as antimicrobial agents - The Times of India

BENGALURU: A research team from the Indian Institute of Science has synthesised a nanomaterial that mimics an enzyme and can disintegrate the cell membranes of a range of disease-causing bacteria. The study, published in the journal ACS Applied BioMaterials.

Highlight on the Cover Page of ChemBioChem

Highlight on the Cover Page of ChemBioChem

Our article titled "Halogen Bonding in Biomimetic Deiodination of Thyroid Hormones and their Metabolites and Dehalogenation of Halogenated Nucleosides" is highlighted on the Cover of ChemBioChem.

Namrata Singh selected for the IUPAC-SOLVAY International Award

Namrata Singh selected for the IUPAC-SOLVAY International Award

Namrata Singh has been selected for the 2020 IUPAC-Solvay International Award for Young Chemists, presented for the best Ph.D. theses in the chemical sciences. She will receive a cash prize of USD 1000 and travel expenses to the 48th IUPAC World Chemistry Congress, 13-20 August 2021, in Montréal, Canada.

Top 10 Indian Science Personalities of 2019

Top 10 Indian Science Personalities of 2019

Mugesh has been featured in the list of Top 10 Indian Science Personalities of 2019 published by Scientific India magazine.

Important to focus beyond conventional realms of chemistry and biology

Important to focus beyond conventional realms of chemistry and biology

In this exclusive interview, Prof. G. Mugesh talks about the importance of interdisciplinary research to work on problems that transcend traditional boundaries of ‘chemistry’ and ‘biology’. Prof. Mugesh was awarded the Infosys Prize 2019 in Physical Sciences for his seminal work in the chemical synthesis of small molecules and nanomaterials for biomedical applications.

Mindset of Problem Solving Important: An Interview by ET Now

Mindset of Problem Solving Important: An Interview by ET Now

Infosys founder Narayana Murthy says while India has made good progress in science and innovation, the ability of problem-solving is still missing among the youth. What can India do to leapfrog in research? Will private funding be the game-changer? ET NOW's Rahul Dayama sat down with Narayana Murthy, Prof. G. Mugesh, Winner in Physical Sciences and Prof. Srinivas Kulkarni, Jury Chair of Infosys Prize for an engaging chat.

An Interview by Vishal Krishna, Business Editor, YourStory

An Interview by Vishal Krishna, Business Editor, YourStory

At the award ceremony of the Infosys Prize 2019 held on January 7, 2020. YourStory caught up with Infosys Founder NR Narayana Murthy, Prof. Srinivas Kulkarni, Jury Chair, Physical Sciences and G. Mugesh in an exclusive interview about startups, research, and fundamental sciences.

Mugesh receives the Infosys Prize 2019 in Physical Sciences

Mugesh receives the Infosys Prize 2019 in Physical Sciences

Mugesh has received the Infosys Prize in Physical Sciences for the year 2019 from Prof. Amartya Sen, Nobel Laureate at a Prize Ceremony held at Taj West End Hotel on January 7, 2020, for his work in the chemical synthesis of small molecules and nanomaterials for biomedical applications.

Artificial Enzymes - What are they? - Winners' Symposium Lecture

Artificial Enzymes - What are they? - Winners' Symposium Lecture

As part of the Infosys Prize Winners' Symposium, G. Mugesh discusses about Artificial Enzymes and how we can use such enzymes to regulate the biological redox processes in the mammalian cells.

G. Mugesh joins the Editorial Board of Chemistry - A European Journal

G. Mugesh joins the Editorial Board of Chemistry - A European Journal

G. Mugesh has been inducted as a new Editorial Board Member of Chemistry - A European Journal, a major international chemistry journal published by the ChemPubSoc Europe. Read an Editorial by Dr Haymo Ross, Editor-in-Chief.

Infosys Prize for G. Mugesh - News Item in Angewandte Chemie

Infosys Prize for G. Mugesh - News Item in Angewandte Chemie

The Infosys Science Foundation has announced its prize winners for 2019 in six categories. The Infosys Prize for Physical Sciences is awarded to Govindasamy Mugesh (Indian Institute of Science, Bangalore) in recognition of his work on the synthesis of small molecules and nanomaterials for biomedical applications....

Mugesh has been selected for the Infosys Prize 2019

Mugesh has been selected for the Infosys Prize 2019

Mugesh has been selected for the Infosys Prize in Physical Sciences for the year 2019. He has been selected for this award for his pioneering work in the chemical synthesis of small molecules and nanomaterials for biomedical applications.

Namrata Singh receives the IIT Bombay Metrohm Young Chemist Award

Namrata Singh receives the IIT Bombay Metrohm Young Chemist Award

Namrata Singh has been awarded the IIT Bombay Metrohm Young Chemist Award 2019 for "Innovation in Research" at an award ceremony held at IIT Bombay on September 17, 2019. The award was given for her research on uncovering the role of an antioxidant nanozyme that provides cytoprotection in Parkinson’s Disease model.

Highlight on the Cover Page of Chemistry - A European Journal

Highlight on the Cover Page of Chemistry - A European Journal

Our paper published in collaboration with Dr Kenta Arai and Prof. Michio Iwaoka on "Modeling Thioredoxin Reductase‐Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH⋅⋅⋅Se Hydrogen Bond through Stabilization of the Mixed Se−S Intermediate" is highlighted on the Cover of Chemistry - An European Journal.

“Reviews Showcase” in Chemistry - A European Journal

“Reviews Showcase” in Chemistry - A European Journal

Our recent concept article on Directing Traffic: Halogen-Bond-Mediated Membrane Transport has been selected by the Editorial Office for the Showcase of outstanding Review-type articles in Chemistry - A European Journal. In this article, we describe a novel strategy involving halogen bonding for increasing the cellular uptake of small molecules and proteins.

“Hot Paper” in Chemistry - A European Journal

“Hot Paper” in Chemistry - A European Journal

Our new paper on modelling the inhibition of selenoproteins by small molecules using cysteine and selenocysteine derivatives has been selected as a "Hot Paper" in Chemistry - A European Journal. We demonstrate, for the first time, that the arylselenium species eliminated from the selenocysteine derivatives exhibit significant redox activity, which may have a significant effect on the cellular redox state during the inhibition of selenoproteins.

“Hot Paper” in Angewandte Chemie

“Hot Paper” in Angewandte Chemie

Our new paper on membrane transport of green fluorescent protein in mammalian cells has been selected as a "Hot Paper" in Angewandte Chemie. We show that the introduction of an iodine atom to one of the tyrosine residues facilitates the cellular entry of green fluorescent proteins, providing a strategy for the delivery of macromolecules into mammalian cells.

In a first, IISc team directly delivers protein into cells - The Hindu

In a first, IISc team directly delivers protein into cells - The Hindu

In a breakthrough that might have huge medical implications, researchers at Bengaluru’s Indian Institute of Science (IISc) have used a novel strategy to directly deliver proteins into mammalian cells. Proteins are big molecules and so cannot enter the cells on their own. So a team from IISc substituted a hydrogen atom of the protein with an iodine atom to achieve a nearly sixfold increase in protein uptake by cells.

ChemistryViews: Halogen-Mediated Transport through Cell Membranes

ChemistryViews: Halogen-Mediated Transport through Cell Membranes

Our work on Halogen-Mediated Membrane Transport, published in Chemistry - A European Journal has been featured on ChemistryViews, Wiley-VCH's chemistry portal. We found that the introduction of iodine atoms into a series of fluorescent molecules (example pictured) remarkably enhances the cellular uptake. Using two iodine atoms, the cellular uptake can be increased to more than 95 % in mammalian cells.

Namrata Singh has been awarded an ACS Poster Prize at the CRSI-NSC-24

Namrata Singh has been awarded an ACS Poster Prize at the CRSI-NSC-24

Namrata Singh has been awarded an ACS poster prize for her work titled "A manganese-based nanozyme for cellular redox regulation", at the 24th CRSI National Symposium in Chemistry (NSC-24), at CLRI, Chennai, during February 8 - 10, 2019.

CRSI Silver Medal by the Chemical Research Society of India

CRSI Silver Medal by the Chemical Research Society of India

Mugesh has been awarded the CRSI Silver Medal for the year 2019 by the Chemical Research Society of India. He delivered the Medal Lecture at the 24th National Symposium in Chemistry held at CLRI, Chennai, during February 8-10, 2019.

“Very Important Paper (VIP)” in Chemistry - A European Journal

“Very Important Paper (VIP)” in Chemistry - A European Journal

According to the evaluation of referees, our paper titled "Halogen-Mediated Membrane Transport: An Efficient Strategy for the Enhancement of Cellular Uptake of Synthetic Molecules", has been designated as Very Important Paper (VIP). Less than 5% of the manuscripts accepted for publication in the journal receive such a positive review.

Punarbasu Roy has been awarded a Poster Prize at the I-DEC-2018

Punarbasu Roy has been awarded a Poster Prize at the I-DEC-2018

Punarbasu Roy has been awarded a poster prize (RSC-Chem.Comm.) for his work titled "Mechanistic investigation of GPx-like activity of V2O5 nanozyme", at the Inter-Disciplinary Explorations in Chemistry (I-DEC-2018) at IISER Bhopal, during December 6 - 8, 2018.

Prof. R.C. Mehrotra Commemoration Lecture Award of ISCA

Prof. R.C. Mehrotra Commemoration Lecture Award of ISCA

Mugesh has been selected for Prof. R.C. Mehrotra Commemoration Lecture Gold Medal of the Indian Science Congress Association (ISCA) for the year 2018-19. He has been invited to deliver the Award Lecture at the 106th Indian Science Congress to be held during January 3-7, 2019.

Sourav Ghosh has been awarded a Poster Prize at the CRSI-NSC-23

Sourav Ghosh has been awarded a Poster Prize at the CRSI-NSC-23

Sourav Ghosh has been awarded a poster prize for his work titled "Nanoisozymes: Crystal-Facet-Dependent Enzyme-Mimetic Activity of V2O5 Nanomaterials," at the 23rd CRSI National Symposium in Chemistry (NSC-23) at IISER Bhopal, during July 13 - 15, 2018.

Author Profile in Angewandte Chemie

Author Profile in Angewandte Chemie

“When I was eighteen I wanted to be a farmer. The natural talent I would like to be gifted with is the ability to learn new languages quickly …” Find out more about Govindasamy Mugesh in his Author Profile.

ACS Chemical Biology - Introducing Our Authors

ACS Chemical Biology - Introducing Our Authors

ACS Chemical Biology showcases the graduate students who contributed significantly to their first paper in the "Introducing Our Authors" section of the journal. The profiles of NaveenKumar, S. K. and SharathBabu, B. N., have been featured in the August 2018 issue of ACS Chemical Biology.

“Hot Paper” in Angewandte Chemie

“Hot Paper” in Angewandte Chemie

Our new paper on redox modulatory Mn3O4 nanozyme with multi-enzyme activity has been selected as a "Hot Paper" in Angewandte Chemie. The nanozyme functionally mimics three major antioxidant enzymes - superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) - and the activity is size as well as morphology-dependent. The nanomaterial provides efficient cytoprotection to human cells in Parkinson's disease model.

Making cellular probes more effective - BusinessLine

Making cellular probes more effective - BusinessLine

Scientists at Indian Institute of Science, Bengaluru have found a way to enhance uptake of fluorescent probes into cells. They have found that by replacing hydrogen atoms at crucial places of napthalimide with iodine or bromide atoms makes it easier to break into cells.

Iodine Magic - A highlight of our recent work in The Hindu

Iodine Magic - A highlight of our recent work in The Hindu

Studying the uptake of thyroid hormone may become easier - Fluorescent probes are routinely used for studying drug delivery, membrane activity and cellular functions. By substituting two hydrogen atoms of a commonly used fluorescent probe (naphthalimide) with iodine, researchers at the Indian Institute of Science (IISc), Bengaluru, have been able to increase the cellular uptake of the probe molecule from 5-8% to 98%.

Namrata Singh Wins a Poster Prize at Gordon Research Conference

Namrata Singh Wins a Poster Prize at Gordon Research Conference

Namrata Singh has been awarded a poster prize for her work on "An antioxidant nanozyme providing cytoprotection in Parkinson’s Disease Model," at the Gordon Research Conference “Metals in Medicine” organized in Proctor Academy, New Hampshire, USA, during June 24 - 29, 2018. The poster has also been selected for a Poster Slam.

IISc team synthesizes artificial enzyme

IISc team synthesizes artificial enzyme

Nanozyme mimics the antioxidant enzyme glutathione peroxidase - Nanomaterials that can behave like human enzymes have now been successfully synthesized by a team of researchers from Indian Institute of Science (IISc), Bengaluru. They produced the new nanozyme — nanomaterial with enzyme-like activity — by using vanadium pentoxide nanocrystals of just 150-200 nm size.

Highlight of our work on Mn3O4 nanozyme in "The Hindu" Newspaper

Highlight of our work on Mn3O4 nanozyme in "The Hindu" Newspaper

A team of researchers from the Indian Institute of Science (IISc) Bengaluru has fabricated a metal oxide nanomaterial that is capable of mimicking all three major cellular antioxidant enzymes, thereby controlling the level of reactive oxygen species (ROS) inside cells. Based on in vitro test results, the nanomaterial appears a promising candidate for therapeutic applications against oxidative stress-induced neurological disorders, particularly Parkinson’s.

Mugesh has been elected as the President of ACES

Mugesh has been elected as the President of ACES

Mugesh has been elected as the President of the Asian Chemical Editorial Society (ACES) for a four-year term starting from 2018. ACES is an organization of 13 major chemical societies in the Asia-Pacific region, which publishes three international research journals: Chemistry – An Asian Journal, Asian Journal of Organic Chemistry (AsianJOC), and ChemNanoMat.

National Prize for Research on Interfaces of Chemistry and Biology

National Prize for Research on Interfaces of Chemistry and Biology

Mugesh has been selected for the National Prize for Research on Interfaces of Chemistry and Biology, awarded by C. N. R. Rao Education Foundation and JNCASR, Bangalore. The award is supported by the AVRA Laboratories Pvt. Ltd., Hyderabad. The award was conferred on him at an award ceremony held on June 5, 2017 at JNCASR, Bangalore.

Mugesh has been selected for the Bhagyatara Award 2016

Mugesh has been selected for the Bhagyatara Award 2016

Mugesh has been selected for the Bhagyatara Award for the year 2016. The award was conferred on him at an award ceremony at Panjab University on April 21, 2017. The award is given annually to an Indian scientist, who has made significant contributions in Applied Science and is actively engaged in research in the University or a research institute in India in the area of Organic Chemistry, Biochemistry or Pharmaceutical Chemistry.

Mugesh has been selected for the Rajib Goyal Prize

Mugesh has been selected for the Rajib Goyal Prize

Mugesh has been selected for the Rajib Goyal Prize in Chemical Sciences by Kurukshetra University for the year 2014-15. The award was conferred on him at an award ceremony on April 11, 2017 at Kurukshetra University. These prizes are instituted to honour Indian scientists who are engaged in advanced research in basic and applied sciences.

Most Popular RSC-OBC Article in 2016

Most Popular RSC-OBC Article in 2016

Santanu Mondal's paper titled "Biomimetic deiodination of thyroid hormones and iodothyronamines - a structure-activity relationship study" has been selected as one of the 10 most popular articles in Organic & Biomolecular Chemistry (RSC) in the year 2016.

Mugesh has been invited to join the Asian Chemical Biology Initiative

Mugesh has been invited to join the Asian Chemical Biology Initiative

Mugesh has joined the Asian Chemical Biology Initiative (ACBI) as a member. This iniative is supported by the JSPS Core-to-Core Program, Japan and around 90 chemical biology professors from Japan, Korea, China, Singapore, UAE, India, New Zealand and emerging countries serve as the members.

Mugesh joins the Editorial Board of Biological Chemistry

Mugesh joins the Editorial Board of Biological Chemistry

G. Mugesh has joined the Editorial Board of Biological Chemistry, published by De Gruyter, Germany. The journal was established by Felix Hoppe-Seyler, a pioneer of Biochemistry and Molecular Biology, in 1877 and was edited by him until 1895. The journal was subsequently edited by the Nobel laureate, Albrecht Kossel, until 1927.

Amit A. Vernekar wins ASDF Best Scientific Researcher Award

Amit A. Vernekar wins ASDF Best Scientific Researcher Award

Amit A. Vernekar has been selected for the "ASDF Best Scientific Research Award" for the year 2016 by the Association of Scientists, Developers and Faculties (ASDF International). The results of 6th ASDF Global Awards 2016 have been declared in a press conference held on December 09, 2016 at Michigan, USA. The winners were selected from 9877 nominations.

Mugesh has been elected as Fellow of INSA

Mugesh has been elected as Fellow of INSA

G. Mugesh has been elected as Fellow of the Indian National Science Academy (INSA), New Delhi.

Highlight on the Cover Page of Organic & Biomolecular Chemistry

Highlight on the Cover Page of Organic & Biomolecular Chemistry

Mammalian selenoenzymes, iodothyronine deiodinases (DIOs), catalyze the tyrosyl and phenolic ring deiodination of thyroid hormones (THs) and play an important role in maintaining the TH concentration throughout the body. These enzymes also accept the decarboxylated thyroid hormone metabolites, iodothyronamines (TAMs), as substrates for deiodination.

Mugesh receives the Shanti Swarup Bhatnagar Prize for the year 2012

Mugesh receives the Shanti Swarup Bhatnagar Prize for the year 2012

Mugesh received the S. S. Bhatnagar Prize for the year 2012 from Dr Harsh Vardhan, Union Minister for Science & Technology on the CSIR Foundation Day Platinum Jubilee Function held on 26th September 2016 at Vigyan Bhawan, New Delhi. The award function was inaugurated by the Prime Minister of India, Shri Narendra Modi.

IISc’s war on India’s killers: Cancer, CVD

IISc’s war on India’s killers: Cancer, CVD

A major research in the Indian Institute of Science (IISc) will target destroying the very heart of the leading cause of mortality in India – cardiovascular diseases (CVD). IISc researchers are looking at developing an oral medication to be taken by CVD patients at the very onset of the condition, not only to prevent any further damage, but cure the patient completely.

Highlight of our Review on the Cover Page in Angewandte Chemie

Highlight of our Review on the Cover Page in Angewandte Chemie

Our recent review on "Chemistry and Biology in the Biosynthesis and Action of Thyroid Hormones" in Angewandte Chemie has been featured on the front Cover Page. This review describes the biosynthesis, transport, metabolism, and mechanism of action of thyroid hormones, as well as thyroid-related disorders.

Mugesh joins the Editorial Advisory Board of ACS Omega

Mugesh joins the Editorial Advisory Board of ACS Omega

Mugesh has been invited to join the inaugural Editorial Advisory Board of ACS Omega, published by the American Chemical Society. ACS Omega is a new open-access publication for chemists, materials scientists, biologists, physicists, engineers and other researchers, that focuses on research with connections to chemistry.

Mugesh joins the Editorial Board of Organic & Biomolecular Chemistry

Mugesh joins the Editorial Board of Organic & Biomolecular Chemistry

Mugesh has been invited to join the Editorial Board of Organic & Biomolecular Chemistry, published by the Royal Society of Chemistry (London). This is a weekly journal for the publication of highly significant original research and reviews in all areas of organic chemistry, including organic synthesis, physical organic chemistry, supramolecular chemistry and bioorganic chemistry.

Santanu Mondal Wins the Chemistry Letters Best Poster Prize

Santanu Mondal Wins the Chemistry Letters Best Poster Prize

Santanu Mondal has been awarded the Chemistry Letters (Chemical Society of Japan) best poster prize at the 13th International Conference on the Chemistry of Selenium and Tellurium (ICCST-13), organized by Gifu University, Gifu, Japan during May 24-27, 2016. He received this prize for his poster titled "Selenium-mediated dehalogenation of thyroid hormones and halogenated nucleosides".

Amit A. Vernekar wins the Best Thesis Award

Amit A. Vernekar wins the Best Thesis Award

Amit A. Vernekar has been awarded Prof. S. Soundararajan Medal (best thesis award) for the academic year 2015-16. His thesis work describes the application of nanomaterials for biomedical applications. Amit has developed a V2O5-nanozyme that can protect human cells from oxidative damage.

Santanu Mondal Wins the ACS Chemical Biology Best Poster Prize

Santanu Mondal Wins the ACS Chemical Biology Best Poster Prize

Santanu Mondal, a Ph.D. student working in Mugesh's laborotory, has been awarded the ACS Chemical Biology best poster prize at the International Symposium on Chemical Biology and Drug Discovery (ISCBDD-2016), organized by the National Institute of Pharmaceutical Education and Research (NIPER), Kolkata, Bose Institute, Kolkata, and Chemical Biology Society (CBS), India during March 1-3, 2016.

Tandrila Das Wins the RSC Best Poster Prize at ICMG-2016

Tandrila Das Wins the RSC Best Poster Prize at ICMG-2016

Tandrila Das, an undergraduate student working in Mugesh's laborotory, has been awarded the Royal Society of Chemistry (RSC) best poster prize for her poster titled "Vacancy-Engineered Nanoceria: Enzyme Mimetic Hotspots for the degradation of Nerve Agents" at the 6th International Conference on Metals in Genetics, Chemical Biology and Therapeutics (ICMG-2016), held at IISc Bangalore, during February 17-20, 2016.

A nanomaterial that can help in degrading nerve damaging chemicals

A nanomaterial that can help in degrading nerve damaging chemicals

A team from IISc has found a material which can be used to degrade the toxic chemicals that inhibit the function of an enzyme, Acetylcholinesterase, which is involved in the breakdown of the nerve transmitter acetylcholine. This in turn can lead to nerve damage, paralysis and even death. Antidotes are available for nerve agent poisoning, but they do not act on the nerve agent itself – they act either on Acetylcholinesterase enzyme or its receptor.

Most Active Nanozyme

Most Active Nanozyme

Nanozymes – enzyme mimetics based on nanomaterials – have potential applications in imaging, diagnostics, and therapeutics, although tuning their activity for specific applications by tailoring their chemical and physical properties remains a challenge. Govindasamy Mugesh and co-workers at the Indian Institute of Science, Bangalore, used a simple co-precipitation method in the presence of base to synthesize a MnFe2O4 nanomaterial.

Mugesh has been elected as Vice President of ACES

Mugesh has been elected as Vice President of ACES

Mugesh has been elected as Vice President of the Asian Chemical Editorial Society (ACES), an organization of 13 major chemical societies in the Asia-Pacific region. ACES publishes three international research journals: Chemistry – An Asian Journal, Asian Journal of Organic Chemistry (AsianJOC), and ChemNanoMat.

Highlight of our recent research in the IISc magazine CONNECT

Highlight of our recent research in the IISc magazine CONNECT

G Mugesh’s laboratory works on developing new therapeutic agents to battle diverse diseases like cancer, renal disease, and neurodegenerative disorder such as Alzheimer's and Parkinson's. These disorders are associated with reactive oxygen species (ROS) - chemically reactive molecules containing oxygen that are important in cell signaling - and oxidative stress......

G. Mugesh has been awarded the J.C. Bose National Fellowship

G. Mugesh has been awarded the J.C. Bose National Fellowship

G. Mugesh has been awarded the prestigious J.C. Bose National Fellowship by the Science and Engineering Research Board, Department of Science and Technology, Government of India, for his work in the area of chemical biology, particularly for his contributions to mechanistic investigations of thyroid hormone action, enzyme mimetic antioxidants and nanomaterials for biomedical applications.

Highlight in Angewandte Chemie

Highlight in Angewandte Chemie

Form and substance: Through observation and careful follow-up on polymorphic forms of thyroxine, Mondal and Mugesh have provided a stunningly simple answer to the apparent non-equivalence of thyroid hormone tablets. A highlight by Prof. Ulrich Schweizer and Prof. Clemens Steegborn in Angewandte Chemie on our recent work on Thyroxine Conformations.

A Spotlight in Chemistry - A European Journal

A Spotlight in Chemistry - A European Journal

Chemistry - A European Journal Spotlights section features a selection of the excellent work that has recently been published in the sister journals. Recently, our work on the structure of thyroxine published in Angewandte Chemie (dx.doi.org/10.1002/anie.201505281) has been highlighted in this section.

Why Hypothyroidism Drugs Act up - The New Indian Express

Why Hypothyroidism Drugs Act up - The New Indian Express

When patients switch brands of their drug for hypothyroidism, they receive either too much or too little of this life-saving hormone. Dr Govindasamy Mugesh’s laboratory at the Department of Inorganic and Physical Chemistry, Indian Institute of Science, has recently come up with an explanation for this highly variable therapeutic property of generic thyroxine between brands.

IISc’s breakthrough in hypothyroidism treatment - Bangalore Mirror

IISc’s breakthrough in hypothyroidism treatment - Bangalore Mirror

Over 200 million people suffer from thyroid hormone deficiencies or hypothyroidism - a condition that manifests as mental slowness, depression, fatigue and weight gain. The condition is treated using synthetic thyroxine that is administered as tablets available from a variety of brands. However, different brands of synthetic thyroxine have been found to be highly variable from each other.

Highlight in Angewandte Chemie

Highlight in Angewandte Chemie

Se-ing and doing: Isoselenazoles are novel, very potent antioxidant derivatives offering remarkable cytoprotection to human cells. Synthetically available in only a few steps, these compounds have the potential to fight diseases caused by oxidative stress. A highlight by Prof. Thomas Wirth in Angewandte Chemie on our recent work on Glutathione Peroxidase and Peroxiredoxin Mimetics.

Debasish Manna wins Best Thesis Award

Debasish Manna wins Best Thesis Award

Debasish Manna has been awarded Prof. S. Soundararajan Medal (best thesis award) for the academic year 2014-15.

Antioxidant panaceas: Isoselenazoles protect cells from oxidative stress

Antioxidant panaceas: Isoselenazoles protect cells from oxidative stress

Panacea, the Greek goddess of universal remedies, is also the name given to any chemical that can supposedly cure all ailments – for example, antioxidants. Since many diseases are either caused by or exacerbated by oxidative stress, the use of antioxidants as therapeutic agents is logical. Novel antioxidants, are several more compounds called isoselenazoles that have been synthesised by a team of scientists from the Indian Institute of Science.

K. Raja wins SBIC/ICBIC17 Student Travel Award

K. Raja wins SBIC/ICBIC17 Student Travel Award

K. Raja has been selected for the student travel award by the Society of Biological Inorganic Chemistry (SBIC) to participate in the ICBIC17 at Beijing during July 20-24, 2015. The selection by the committee was based on the submitted abstract and the quality of the applicant.

Amit A. Vernekar is one of the Finalists of the Reaxys PhD Prize

Amit A. Vernekar is one of the Finalists of the Reaxys PhD Prize

Amit A. Vernekar has been selected as one of finalists of the 2015 Reaxys PhD prize. The Reaxys PhD Prize recognizes young chemists conducting original and innovative research in organic, organometallic and inorganic chemistry. The finalists will present their research at the 2015 Reaxys PhD Prize Symposium, September 7-8, 2015, in Hong Kong.

Replacement of single atom alters thyroid biochemical cascade

Replacement of single atom alters thyroid biochemical cascade

More than 200 million people worldwide suffer from thyroid related disorders like hyperthyroidism, hypothyroidism, goitre, Hashimoto’s thyroiditis, thyroid cancer etc. Most of these are treated with synthetic form of T4 for hypothyrodism and thiouracil-based drugs for hyperthyroidism. However, small variations in the drug concentration can lead to adverse effects.

Debasish Bhowmick's Paper is a VIP in Angewandte Chemie

Debasish Bhowmick's Paper is a VIP in Angewandte Chemie

Debasish Bhowmick's article titled "Highly Efficient Glutathione Peroxidase and Peroxiredoxin Mimetics Protect Mammalian Cells against Oxidative Damage" a Very Important Paper (VIP) in Angewandte Chemie. Less than 5% of the manuscripts receive such a positive evaluation.

Mugesh is in the list of Top 10 Famous Indian Science Personalities

Mugesh is in the list of Top 10 Famous Indian Science Personalities

Mugesh has been featured in the list of Top 10 Famous Indian Science Personalities of 2014 published by Scientific India magazine. He has been selected based on the overall impact of his research work carried out in the year 2014.

Amit A. Vernekar wins the GYTI Award

Amit A. Vernekar wins the GYTI Award

Amit A. Vernekar has been awarded the prestigious Gandhian Young Technological Innovation (GYTI) award for the year 2015 for his work on “Novel nanozyme technology for combating oxidative stress related disorders”. He is one of the 17 students selected for this award from over 1700 nominations in 50 technology domains.

Amit A. Vernekar wins the BVS2015 Oral Presentation Prize

Amit A. Vernekar wins the BVS2015 Oral Presentation Prize

Amit A. Vernekar has been awarded BVS2015 Oral Presentation Prize (First Prize) at the 4th Bharatiya Vigyan Sammelan-Youth Oriented, at Goa. This event was organized to provide a platform for the youth and around 414 abstracts were received. Prizes were awarded to the submissions that had potential for research in the future.

Hot Paper in Chemistry - A European Journal

Hot Paper in Chemistry - A European Journal

The paper from the work of Debasish Manna and Santanu Mondal titled "Halogen Bonding Controls the Regioselectivity of the Deiodination of Thyroid Hormones and their Sulfate Analogues", published in Chemistry - A European Journal has been selected as Hot Paper by the Editors of the Journal. The main conclusion drawn from this study is that the halogen bonding is one of the crucial factors that control the regioselectivity.

IISc: novel way to reduce cell damage found

IISc: novel way to reduce cell damage found

Preliminary studies have shown that vanadia nanowires can reduce cell damage and blunt the effect of one of the factors responsible for the onset of several diseases such as cancer, diabetes, cardiovascular diseases and ageing. Vanadia nanowires functionally mimic a major antioxidant enzyme in mammalian cells by using cellular thiols. The results were published in the journal Nature Communications.

Mugesh joins the Editorial Board of Bioorganic Chemistry

Mugesh joins the Editorial Board of Bioorganic Chemistry

G. Mugesh has joined the Editorial Board of Bioorganic Chemistry published by Elsevier.

Debasish Manna wins Lilly Outstanding Thesis Award

Debasish Manna wins Lilly Outstanding Thesis Award

Debasish Manna has been awarded the Eli Lilly and Company Asia Outstanding Thesis Award for the year 2014. These awards are given to students who made significant contributions in the field of medicinal chemistry, organic synthesis, computational chemistry, structural biology or analytical chemistry.

Mugesh receives Dr R. A. Mashelkar Endowment Lecture Award

Mugesh receives Dr R. A. Mashelkar Endowment Lecture Award

G. Mugesh has received "Dr. R.A. Mashelkar Endowment Lecture Award" in Advanced Materials from the National Chemical Laboratory (NCL), Pune. He delivered the endowment lecture on August 11, 2014 at NCL, Pune.

Mugesh joins the Editorial Board of Scientific Reports

Mugesh joins the Editorial Board of Scientific Reports

G. Mugesh has been invited to join the Editorial Board of Scientific Reports, a journal of Nature Publishing Group.

Geethika is selected for the Prime Minister's Fellowship

Geethika is selected for the Prime Minister's Fellowship

Ms. M. Geethika has been awarded the prestigious Prime Minister's Fellowship for Doctoral Research. This scheme is aimed at encouraging young, talented, enthusiastic and result-oriented scholars to take up industry-relevant research.

Mugesh receives Dr. S. K. Pradhan Endowment Lecture Award

Mugesh receives Dr. S. K. Pradhan Endowment Lecture Award

G. Mugesh has received "Dr. S.K. Pradhan Endowment Lecture Award" in Pharmaceuticals Science & Technology for the year 2013-2014 from Institute of Chemical Technology (ICT), Mumbai. He delivered the endowment lectures on January 28, 2014.

Santanu Mondal receives Best Poster Award

Santanu Mondal receives Best Poster Award

Poster titled "Deiodination of Thyroid Hormones and Iodothyronamines by Iodothyronine Deiodinase Mimics" by Santanu Mondal at the 5th Annual Meeting of the Proteomics Society of India on "Medical Proteomics" during November 28-30, 2013, has received the "Best Poster Award".

Mugesh receives "Asian Rising Star" commemorative plaque

Mugesh receives "Asian Rising Star" commemorative plaque

G. Mugesh has been invited by the Federation of Asian Chemical Societies (FACS) to deliver a lecture in the "Asian Rising Stars" special session dedicated to young scientists at the 15th Asian Chemical Congress (ACC) during August 19-23, 2013 in Singapore. He has received a Commemorative plaque from Professor Ei-ichi Negishi, Nobel Laureate in Chemistry during the ACC.

Debasish Bhowmick wins best poster award at ICCST-12

Debasish Bhowmick wins best poster award at ICCST-12

Poster titled "Role of Steric and Electronic Effects on the Glutathione Peroxidase Activity of Amine-based Diaryl Diselenides", presented by Debasish Bhowmick at the 12th International Conference on the Chemistry of Selenium and Tellurium (ICCST-12) at Cardiff University, UK, during July 22-26, 2013, received the Best Poster Award.

Amit A. Vernekar wins best poster award at Indo-US Symposium

Amit A. Vernekar wins best poster award at Indo-US Symposium

Poster titled "Production of Graphene, Noncovalent Functionalization and its Remarkable Antioxidant Enzyme-like Characteristics", presented by Amit A. Vernekar at the Indo-US Symposium on "Molecular Materials" at IISc, Bangalore, during July 15-17, 2013 received the Best Poster Award.

Amit Vernekar wins best poster award at Materials Genome Conference

Amit Vernekar wins best poster award at Materials Genome Conference

Poster titled "Remarkable Peroxynitrite Scavenging Activity of Hemin Functionalized Graphene Nanosheets", presented by Amit A. Vernekar at the First National Conference on Mapping the "Materials Genome" at Shiv Nadar University, Dadri, during March 8-10, 2013 received the Best Poster Award.

Debasish Manna selected for the 63rd Lindau Nobel Laureate Meeting

Debasish Manna selected for the 63rd Lindau Nobel Laureate Meeting

Debasish Manna has been selected to participate in the 63rd Lindau Nobel Laureate Meeting to be held during June 30-July 05, 2013, in Lindau, Germany. In these meetings, several Nobel Laureates meet the next generation of scientists: undergraduates, PhD students, and post-doc researchers from all over the world.

Mugesh is elected as Fellow of the Royal Society of Chemistry

Mugesh is elected as Fellow of the Royal Society of Chemistry

G. Mugesh has been elected as Fellow of the Royal Society of Chemistry (FRSC), London, UK. Achieving Fellow status in the chemical profession denotes to the wider community a high level of accomplishment as a professional chemist.

Amit A. Vernekar wins best poster award at NSC-15

Amit A. Vernekar wins best poster award at NSC-15

Poster titled "Peroxynitrite Reductase and Isomerase Activities of Graphene-Hemin Hybrid Nanosheets", presented by Amit A. Vernekar at the 15th CRSI National Symposium in Chemistry (NSC-15) at Banaras Hindu University, Varanasi, during February 1-3, 2013 received the Best Poster Award.

Mugesh wins Shanti Swarup Bhatnagar Prize 2012

Mugesh wins Shanti Swarup Bhatnagar Prize 2012

G. Mugesh has been selected for the Shanti Swarup Bhatnagar Prize in Chemical Sciences for the year 2012, in recognition of his original contributions to the understanding of the thyroid hormone action and metallo-beta-lactamase-induced antibiotic resistance through the creative application of inorganic and organic chemistry.

Mugesh elected as Fellow of the National Academy of Sciences, India

Mugesh elected as Fellow of the National Academy of Sciences, India

G. Mugesh has been elected as Fellow of the National Academy of Sciences, India (NASI) for the year 2012 in the area of Physical Sciences.

Mugesh joins the Editorial Board of ABB

Mugesh joins the Editorial Board of ABB

G. Mugesh has joined the Editorial Board of Archives of Biochemistry & Biophysics published by Elsevier.

IIT Bombay - Best Review Paper Award

IIT Bombay - Best Review Paper Award

One of G. Mugesh's papers titled "Heteroatom-directed Aromatic Lithiation: A Versatile Route to the Synthesis of Organochalcogen Compounds" has received the IIT Bombay Best Review Paper Award for the year 2011. This accounts, published during Ph.D. at IITB with Prof. H. B. Singh, was selected based on 10-years citation data.

Mugesh joins the Editorial Advisory Board of BBJNTCT

Mugesh joins the Editorial Advisory Board of BBJNTCT

G. Mugesh has joined the Editorial Advisory Board of Biochemical and Biophysical Journal of Neutron Therapy & Cancer Treatments, published by Research Publishers Inc., USA