Important to focus beyond conventional realms of chemistry and biology

January 16, 2020

In this exclusive interview, Prof. G. Mugesh talk about the importance of interdisciplinary research to work on problems that transcend traditional boundaries of ‘chemistry’ and ‘biology’. Prof. Mugesh was awarded the Infosys Prize 2019 in Physical Sciences for his seminal work in the chemical synthesis of small molecules and nanomaterials for biomedical applications.

Mindset of Problem Solving Important: An Interview by ET Now

January 7, 2020

Infosys founder Narayana Murthy says while India has made good progress in science and innovation, the ability of problem-solving is still missing among the youth. What can India do to leapfrog in research? Will private funding be the game-changer? ET NOW's Rahul Dayama sat down with Narayana Murthy, Prof. G. Mugesh, Winner in Physical Sciences and Prof. Srinivas Kulkarni, Jury Chair of Infosys Prize for an engaging chat.

An Interview by Vishal Krishna, Business Editor, YourStory

January 7, 2020

At the award ceremony of the Infosys Prize 2019 held on January 7, 2020. YourStory caught up with Infosys Founder NR Narayana Murthy, Prof. Srinivas Kulkarni, Jury Chair, Physical Sciences and G. Mugesh in an exclusive interview about startups, research, and fundamental sciences.

Mugesh receives the Infosys Prize 2019 in Physical Sciences

January 7, 2020

Mugesh has received the Infosys Prize in Physical Sciences for the year 2019 from Prof. Amartya Sen, Nobel Laureate at a Prize Ceremony held at Taj West End Hotel on January 7, 2020, for his work in the chemical synthesis of small molecules and nanomaterials for biomedical applications.

Artificial Enzymes - What are they? - Winners' Symposium Lecture

January 6, 2020

As part of the Infosys Prize Winners' Symposium, G. Mugesh discusses about Artificial Enzymes and how we can use such enzymes to regulate the biological redox processes in the mammalian cells. 

G. Mugesh joins the Editorial Board of Chemistry - A European Journal

January 1, 2020

G. Mugesh has been inducted as a new Editorial Board Member of Chemistry - A European Journal, a major international chemistry journal published by the ChemPubSoc Europe. Read an Editorial by Dr Haymo Ross, Editor-in-Chief. 

Infosys Prize for G. Mugesh - News Item in Angewandte Chemie

December 17, 2019

The Infosys Science Foundation has announced its prize winners for 2019 in six categories. The Infosys Prize for Physical Sciences is awarded to Govindasamy Mugesh (Indian Institute of Science, Bangalore) in recognition of his work on the synthesis of small molecules and nanomaterials for biomedical applications....

Mugesh has been selected for the Infosys Prize 2019

November 7, 2019

Mugesh has been selected for the Infosys Prize in Physical Sciences for the year 2019. He has been selected for this award for his pioneering work in the chemical synthesis of small molecules and nanomaterials for biomedical applications.

Namrata Singh receives the IIT Bombay Metrohm Young Chemist Award

September 17, 2019

Namrata Singh has been awarded the IIT Bombay Metrohm Young Chemist Award 2019 for "Innovation in Research" at an award ceremony held at IIT Bombay on September 17, 2019. The award was given for her research on uncovering the role of an antioxidant nanozyme that provides cytoprotection in Parkinson’s Disease model.

Highlight on the Cover Page of Chemistry - A European Journal

August 7, 2019

Our paper published in collaboration with Dr Kenta Arai and Prof. Michio Iwaoka on "Modeling Thioredoxin Reductase‐Like Activity with Cyclic Selenenyl Sulfides: Participation of an NH⋅⋅⋅Se Hydrogen Bond through Stabilization of the Mixed Se−S Intermediate" is highlighted on the Cover of Chemistry - An European Journal. 

“Reviews Showcase” in Chemistry - A European Journal

July 2, 2019

Our recent concept article on Directing Traffic: Halogen-Bond-Mediated Membrane Transport has been selected by the Editorial Office for the Showcase of outstanding Review-type articles in Chemistry - A European Journal. In this article, we describe a novel strategy involving halogen bonding for increasing the cellular uptake of small molecules and proteins.

“Hot Paper” in Chemistry - A European Journal

May 25, 2019

Our new paper on modelling the inhibition of selenoproteins by small molecules using cysteine and selenocysteine derivatives has been selected as a "Hot Paper" in Chemistry - A European Journal.  We demonstrate, for the first time, that the arylselenium species eliminated from the selenocysteine derivatives exhibit significant redox activity, which may have a significant effect on the cellular redox state during the inhibition of selenoproteins.

“Hot Paper” in Angewandte Chemie

May 8, 2019

Our new paper on membrane transport of green fluorescent protein in mammalian cells has been selected as a "Hot Paper" in Angewandte Chemie.  We show that the introduction of an iodine atom to one of the tyrosine residues facilitates the cellular entry of green fluorescent proteins, providing a strategy for the delivery of macromolecules into mammalian cells.

In a first, IISc team directly delivers protein into cells - The Hindu

April 21, 2019

In a breakthrough that might have huge medical implications, researchers at Bengaluru’s Indian Institute of Science (IISc) have used a novel strategy to directly deliver proteins into mammalian cells. Proteins are big molecules and so cannot enter the cells on their own. So a team from the institute’s Department of Inorganic and Physical Chemistry substituted a hydrogen atom of the protein with an iodine atom to achieve a nearly sixfold increase in protein uptake by cells.

ChemistryViews: Halogen-Mediated Transport through Cell Membranes

March 8, 2019

Our work on Halogen-Mediated Membrane Transport, published in Chemistry - A European Journal has been featured on ChemistryViews, Wiley-VCH's chemistry portal. We found that the introduction of iodine atoms into a series of fluorescent molecules (example pictured) remarkably enhances the cellular uptake. Using two iodine atoms, the cellular uptake can be increased to more than 95 % in mammalian cells.


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